BACKGROUND and AIMS: CD24 was overexpressed in gastric carcinomas and positive CD24 expression correlates significantly with lymphatic invasion, blood vessel invasion and poor survival in gastric carcinomas.We therefore suggested that CD24 would be a new molecular target for therapeutic strategies.In the present study, we aimed to investigate the effects of CD24 down-regulation using monoclonal antibodies (mAb) in gastric cancer cells in vitro and in vivo. \nMETHODS: Gastric cancer SGC-7901 cells were treated with Anti-CD24 mAb ,and the effects on growth and apoptosis were evaluated in vitro and vivo.\nRESULTS: We found that Anti-CD24 mAb could induce the apoptosis of cultured SGC-7901 cells and anti-CD24 mAb treatment inhibited the tumor growth after cancer cell grafting and enhanced the cell apoptosis inside the tumor tissue. \nCONCLUSIONS: Anti-CD24 mAb targeting therapy provides a new avenue toward treating gastric cancer.
Introduction: Severe traumatic brain injury has important consequences on all organs and systems. Stress-induced ulcer, complicated with digestive bleeding, was frequently encountered in these patients.\nThe objective of the experiment was to determine occurrence of acute stress-induced lesion with hemorrhagic potential in rats suffering a severe traumatic brain injury. \nThe aim of the experiment was to verify the clinical observation that severe traumatic brain injury cause erosion and ulcers of digestive mucosa, frequently complicated with digestive bleeding.\nWorking hypothesis: Severe traumatic brain injury favors digestive bleeding occurrence.\nMaterial and method: The experiment was performed in Experimental Medicine Center of the University of Medicine and Pharmacy Cluj-Napoca, in compliance with legislation regarding animal research. The experiment was done on 20 Wistar rats, divided into 2 groups: control and experimental. Animals in group 2 were produced severe traumatic brain injury. After sacrificing the animals the digestive tract was examined macro- and microscopically. \nResults: In the group with traumatic brain injury congestion and edema of gastric mucosa, with hemorrhages, erosions and acute ulcers were found. In 6 animals from the experimental group (60%) large blood clots and gastrorrhagia were found. \nConclusions: Severe traumatic brain injury favors occurrence of local necrotic-hemorrhagic lesions (erosions, ulcers) of gastric mucosa, which frequently is complicated with digestive bleeding.
We present the case of a 55 years old patient, man, (F.A), received of a level IV trauma centre, anxious, tachypnoea, with penetrating foreign body with a diameter of a 4 cm. and length 50 cm., near vertebral right side (at the D4 level with direction toward left thorax), subcutaneous emphysema at this level, absence of the respiratory noises on the left thorax and diminish these on the opposite side. Left chest drainage revealed hemo pneumothorax. \nWe proceed (under deep sedation and analgesia) to air medical evacuation to a regional trauma center.\nA complex imaging investigation has been performed in ED and has no identified than left pulmonary contusion. Emergency surgical intervention practiced foreign body extraction, extensive exploration, regulate and surgical treatment of the wound trajectory. \nPostoperative evolution of without no longer has, the patient was discharged from hospital after 10 days.\n\nConclusions\n• patient has been considered as a life threatening situation about up to the certainly exclusion of all critical or potential fatal lesions \n• assessment plan and the investigation strategy necessitated special adaptation and extension because of the foreign body penetration particularities and suspicion of visceral tissues and spinal lesions\n• minor lesion balance sheet of this patient must be considered as an exception fortune\n• medical team must remain prepared for the worst case scenario
This paper reports the strength development of high performance concrete in which Ultra Fine Steatite Powder (UFSP) is used as admixture. Concrete cubes and cylinders were prepared for compressive strength of 60 Mpa. The effect of varying dosage of ultra fine steatite powder is discussed in terms of cubes and cylinders. The specimens are tested on 3, 7,14,28,56 and 90 days strength, also the effect of M-S-H formation in the early ages of concrete are discussed. The workability was achieved by incorporating modified polycarboxylic ether as super plasticizers. It is observed that the addition of ultra fine steatite powder of about 5%, 10% and 15% gives a considerable increase in strengths.
Sodium selenite is one of the most toxic selenium compounds. In this study the oral subacute toxicity of sodium selenite at two doses was evaluated. Male Wistar rats were used, which were randomly divided in one of the three experimental groups consisting in 5 rats each: Control, Se1 (1 mg Se+4 equivalent/kg body weight) and Se3 (3 mg Se+4 equivalent/kg body weight). All treatments were administered once a day for 10 consecutive days and the animals were sacrificed on the 11th day. Selenite interfered with the growth gain and caused an increase in ALT, AST and GGT activities as well as in the levels of total and direct bilirubin, serum iron, total cholesterol, HDL-cholesterol and LDL-cholesterol, as well as a decrease in WBC and RBC numbers and in HGB concentration. In the Se1 and Se3 groups hydropic degeneration, perivascular edema, necrosis and anuclear cells were observed in the liver, while in the kidney hydropic degeneration, congestion and vascular ectasia were observed. Sodium selenite toxicity was shown to be dose-dependent.