Obesity is associated with inflammation, the main mechanism of atherosclerosis and insulin resistance. In such condition, inflammatory markers such as proinflammatory cytokines (e.g interleukin-18) and acute-phase proteins (e.g C-reactive protein) elevate in circulating. IL-18 establishes the relation between metabolic syndrome and arteriosclerosis (9), it is the important regulator of acquired and intrinsic immune responses (10) and has a role in discordance of platlets. CRP also is a special inflammation marker and has a role in pathogenesis of chronic inflammatory diseases such as cardiovascular diseases diabetes and cancer. Performing regular exercise training result in reducing inflammatory markers levels released from adipose tissue and thus decrease the risk of chronic disease. The purpose of this study was to survey changes of serum levels of interleukin-18 and high-sensitivity C-reactive protein following twelve weeks resistance training in obese men. Eighteen obese men (28.0 ± 5.2 yr, 175.7 ± 5.7 cm, 94.4 ± 8.3 kg, 31.7 ± 3.6 kg/m2) were randomly placed at one of two groups: training and control. For all subjects, height, weight, body mass index, body fat percent, serum levels of IL-18, and hsCRP (after12-h fasting) were assessed prior to, and after training. Strength training protocol consisted of twelve weeks weight training (3 sessions per week, 10 stations, 3 sets 8-12 repetitions in each station, intensity 60-80% of one repetition maximum, rest between sets 1 min and between stations 2 min, duration of main training 60 min per each session). Data were analyzed by SPSS16 software and using Independent and Paired t-tests. Statistical significance was accepted at P<0.05. Following twelve weeks resistance training, serum levels of IL-18 (t =0.211, sig. =0.055) and hsCRP (t =0.554, sig. =0.061) were decreased in training group, but it wasn\'t statistically significant. Also, no significant changes were observed in control group (P >0.05).\nIt doesn\'t appear that doing resistance training for twelve weeks cause to significant changes in circulating levels of IL-18 and hsCRP in obese men. Totally, the advantage of resistance training in intervention for preventing and curing obesity can be because of known benefits of resistance training on strength and muscle mass. This is possible to be a benefit for developing performance and capabilities of daily life activities performance in obese individuals (36). Cross sectional studies have shown that muscle mass, independent of cardiorespiratory fitness levels, has inverse relationship to multi-cause mortality (37) and metabolic syndrome (38). Evidence show that maintance of a great muscle mass is possible to decrease metabolic risk factors related to cardiovascular diseases (obesity, dyslipidemia and type II diabetes)