A B S T R A C T\nIntroduction. A reliable assessment of the environmental safety of construction and development territory is a pressing task of construction science. The purpose of this study is to develop a methodology for assessing environmental safety, taking into account the whole variety of environmental factors. The task of the study is to justify conceptual approaches and evaluation principles.\nMethodology of carrying out work. Identification of estimated indicators, composition of environmental safety factors and development of a model and methodology for assessment of environmental safety at all stages of the investment project life cycle based on them.\nResults. The studies made it possible to develop a well-founded model and methodology for assessing environmental safety, taking into account polluting, influencing factors in a complex relationship, as well as indirect and delayed impact of the construction facility on the environment, on the environmental safety of the territory of the building, construction facility and the population.\nConclusions. The methodology of environmental safety assessment allowed to develop an environmental passport for each assessed territory, each object. The environmental passport reflects the current state of environmental safety, ecological reserve of the territory, threshold of environmental safety, range of stable state. The use of an environmental passport in design allows to ensure environmental safety, quality of life and health of the population.

The aim of present study was to prepare Triamcinolone acetonide (TA) loaded NLCs hydrogel for antipsoriatic activity. Nanostructured lipid carriers (NLCs) was prepared by using solvent diffusion and high pressure homogenization methods. NLCs dispersion was characterized by particle size, zeta potential, scanning electron microscopy (SEM), differential scanning calorimetry, and an in vitro release study. Optimized NLC incorporated into the hydrogel and characterized for rheological properties, drug content, in-vitro drug release, stability study, skin irritation and antipsoriatic activity for optimized batch of hydrogel. Optimized NLCs loaded with TA were exhibited spherical shape with particle size 286.1nm, polydispersity index 0.317, zeta potential -21.9 mV and entrapment efficiency 86.19% respectively. The drug release of optimized batch was 8.34 % and 88.84% at 1h & 8h respectively. The release kinetics of the optimized NLCs best fitted the peppas-korsmeyer model. The results of NLC hydrogel formulations were spreadability 27.4-11.76 g.cm2/sec, drug content 65.6%-74.50%, in vitro drug release 85.52%, primary irritation index was 0.0752, it indicates barely perceptible irritation. Histopathological studies showed that, in psoriasis-induced animal treated with TA loaded NLC hydrogel, marked reduction in thickness of epidermis, as compared to conventional gel formulation. It shows the increase % orthokeratosis 88.69% and % drug activity 54.23% than the marketed formulation. The present results demonstrated that hydrogel based NLC shows the better and effective drug delivery for the management of psoriasis.

This study examined the direct and indirect impact of foreign direct investment (FDI) on poverty reduction in Nigeria using the Autoregressive Distributed Lag (ARDL) framework for the period, 1980 – 2019. The results of the study reveal that foreign direct investment exerted a significant positive effect on economic growth and economic growth in turn significantly contributes to poverty reduction within the period of review, 1980-2019. This implies that FDI indirectly contributes to poverty reduction via economic growth in Nigeria. Regarding the direct impact of FDI on poverty reduction, the study shows that FDI significantly exerted an adverse effect on poverty via relatively low income and loss of jobs. Similarly, the study shows that wage and private sector credit contribute to poverty reduction. With this, the study recommends among others that there is a need for policies that promote FDI in capital and labour- intensive sectors, as well as full implementation of the local content requirement law. However, the result of this study is not without limitations: data inconsistency and a limited number of observations, which are common in developing countries. Nevertheless, this study contributes to the literature on the FDI-poverty reduction relationship.

This research objectives to investigate the influence of flypaper effect on regional generated revenue, general allocation fund, fiscal capacity, and excess of budget calculation towards the local expenditure in regency and municipality in South Sumatera. This research uses the secondary data are published by Indonesia Supreme Audit Institution. The object of this reseach is 14 regencies and 4 municipilities in South Sumatera. This research uses panel data regression analysis. \nThe result showed that regional generated revenue has not influence on local expenditure, meanwhile general allocation fund, fiscal capacity, and excess budget calculation have influence on local expenditure.This study also showed the occurrence of flypaper on the manage of the local expenditure in regency and municipality in South Sumatera province during five years

Introduction: The aims of this study were molecular analysis of fosfomycin resistance and extended spectrum betalactames (ESBLs) among E. coli isolates from kidney transplant patients (KTPs) in Tehran, Iran.\nMaterials and Methods: A total of 60 clinical isolates of uropathogenic E. coli were collected from 3 kidney transplant centers from April to May 2019. Antimicrobial susceptibility testing (AST), determination of minimum inhibitory concentration(MIC) ESBL screening was done based on the protocols of CLSI. The presence of blaTEM, blaSHV, and blaCTX-M , fosA3 , fosC2 genes and existence of mutation among murA, glpT , uhpT, cya genes were evaluated by PCR and further sequencing. Measurement of carbohydrate phosphate transporter activity was done by real time PCR assay.\nResults: By AST, the most resistant and susceptibility was to ampicillin (86%) and to ertapenem and doripenem(100%) respectively. By E- test, 1.6% of E.coli isolates were fosfomycin resistant. The frequency of ESBL producer E. coli isolates in KTPs was 33.4%\n with the most frequentency of blaTEM (55%) gene. Also, some mutations in murA,uhpT and glpTgenes were identified in resistant samples. No fosA3 and fosC2 plasmid genes were detected. By qPCR the expression of uhpT gene increases 32 times in a susceptible isolate. \nConclusions: High resistance to β-lactams antibiotics among E. coli isolates of UTIs in KTPs remains a serious clinical challenge but no correlation between ESBL production and fosfomycin resistant was detected. Resistant rate to fosfomycin was low and the most cause of resistant was variations in chrosomal genes.

The article analyzes a wide range of maps (both existing and under development) that record architectural monuments and modern construction sites. It considers the possibilities of the cartographic method, which assists in the professional activities of various fields: architectural theory and practice, cultural and educational tourism, museology, etc. \nThe goal of this study is to analyze and classify the available architectural maps by purpose, content, scale, and spatial coverage in the context of their cultural and scientific potential. Its study materials are the maps themselves being graphic media representing unusual samples of material culture and supplying scientific knowledge with important information. It is noted that the cultural approach to the study of both the phenomenon itself and the potential of architectural maps is just beginning to be applied. This approach, however, is the thing that can provide the most prominent results for a comprehensive study of the external manifestations and internal content, the cultural meanings of historical monuments as well as modern structures placed on the various versions of such maps. It is pointed out that the cartographic method aims at identifying the geographic distribution of various architectural monuments and the study of historical style phenomena \"in space and in time\". Attention is drawn to the type and meaningful content of maps, functional features are revealed, a brief methodology for their application is given, and their scientific potential is noted. The possibilities of various mapping options are presented as one of the methods in the study of perception, starting from a single monument to the urban space and the whole region of their location. It is demonstrated that mapping architectural heritage helps to transform theoretical data into accessible visual form.

The distinction between the origin of a language and the origin of a people has been obvious among researchers already since the 19th century. The linguistic and genetic characteristics of cultural groups may behave very differently. However, despite the difficulties listed, it is by no means impossible to study genetic and linguistic features in a common framework. Historical genetics is a powerful tool for analysing migration routes, disjunction and admixtures of biological groups and their demographic expansions or compressions. Taking into account the above observations, we analyse whether the occurrence of a language family and subfamily correlates with certain Y-chromosome subgroups. We conclude that simple mathematical Pearson correlation between language families and deep Y-DNA haplogroup assignments can significantly contribute to the resolution of problems debated among linguists, especially in resolving the upstream phylogeny of Indo-European languages between Proto-Indo-European and well-established subfamilies. Our data also reinforces former observations regarding the genetic origin of proto-Uralic speaking groups and suggests new aspects for understanding the Y-DNA of proto-Altaic speakers. Our study proves that analysing correlations between language families and Y-DNA subhaplogroups is valid but should be based on high resolution Y-DNA data with deep subgroups younger than 5000 years, to obtain meaningful results.

This study investigated the antecedents that influence users' acceptance of robots as they appear in daily life. The data used in the analysis is the 2022 Intelligent Information Society User Panel Survey data. As a result of the analysis, there was no difference in gender in the demographic variables used as control variables, and users in the younger age group showed a high intention to use robot technology. Beliefs about the usefulness of robots were found to increase the intention to use robot technology. Among robot commercialization beliefs, beliefs about the commercialization of baby care robots and disabled care robots were found to lower the intention to use robot technology. On the other hand, student education robots and construction site work robots were found to increase the intention to use robot technology. In the case of future privacy protection beliefs, beliefs about future expansion of privacy exposure were found to increase the intention to use robot technology. These results provide academic implications on the role of beliefs in consumer acceptance of robots awaiting future commercialization and also provide implications for practical preparation.

Modern analytical systems aimed at identifying terrorist threats often make mistakes resulting from fundamental perceptual and decision-making mechanisms that are formed from the early stages of human development. This article focuses on the analysis of these errors, pointing out that both in the structures responsible for security and among those involved in terrorist activities, decision-making processes are determined by the same psychological and cognitive mechanisms. Paradoxically, regardless of the side of the conflict in the war on terror, erroneous situational judgments, cognitive heuristics, and limitations resulting from perceptual biases lead to inadequate responses and incorrect forecasts. The authors ask the question: what are the reasons for perceptual errors in the development of forecasts by analytical centers aimed at identifying terrorist threats? The article also presents the causes of these phenomena and their consequences for antiterrorist policy, indicating the need to introduce new methods of data analysis and strategies to reduce cognitive biases in threat identification.